Correlation between CD44+ cancer stem cell expression and histopathological types of nasopharyngeal carcinoma

Background: Nasopharyngeal carcinoma (NPC) recurrency rate is still high despite patients receiving complete treatment. The response to treatment may vary depending on the type of histopathology and Epstein-Barr virus, however mechanism remains unclear. Recent studies have found that there a relationship between presence cancer stem cells (CSCs). CD44+ cause be resistant Therefore, this cross-sectional study aims determine correlation CD44 + cell expression histopathological types NPC. Method: Samples were obtained from NPC biopsies I, II, III (based WHO criteria), who had not received prior was examined using immunohistochemistry methods by staining monoclonal antibodies. degree membrane based immunoreactive score scale or Remmele index scale. Results: Most (21 patients, 50%), followed II (18 42.86%), I (3 7.14%). showed one patient moderate positive two high-positive expression. In 10 eight high-positive. III, low-positive, 11 nine Statistical analysis difference three statistically significant. Conclusion: There no correlations NPC.